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Antipain dihydrochloride
CAS No. 37682-72-7
Antipain dihydrochloride( —— )
Catalog No. M34163 CAS No. 37682-72-7
Antipain dihydrochloride (Antipain 2HCl) is a protease inhibitor derived from Actinomycetes that exhibits analgesic activity and inhibits X-ray-induced chromosomal aberrations in human lymphocytes.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 105 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameAntipain dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionAntipain dihydrochloride (Antipain 2HCl) is a protease inhibitor derived from Actinomycetes that exhibits analgesic activity and inhibits X-ray-induced chromosomal aberrations in human lymphocytes.
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DescriptionAntipain dihydrochloride is a protease inhibitor isolated from Actinomycetes. Antipain dihydrochloride inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain dihydrochloride restricts uterine DNA synthesis and function in mice.
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In Vitro——
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In VivoThe intact, cycling female mice received subcutaneous injections of Antipain dihydrochloride (3 mg) for 16 days, their uteri shows significant diminution in weight and total DNA when compared to untreated controls.Antipain dihydrochloride (100 μg/g body wt; i.p.; at 12h intervals from 0 to 120 h or 240 to 360 h) shows inhibitory effect on Urethane-induced lung neoplasia in mice.
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetSerine Protease
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RecptorProtease
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Research Area——
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Indication——
Chemical Information
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CAS Number37682-72-7
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Formula Weight677.62
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Molecular FormulaC27H46Cl2N10O6
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Purity>98% (HPLC)
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Solubility——
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SMILESO=CC(CCCNC(N)=N)NC(C(C(C)C)NC(C(CCCNC(N)=N)NC(NC(CC1=CC=CC=C1)C(O)=O)=O)=O)=O.Cl.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. DiPaolo JA, et al. Antipain inhibits N-methyl-N'-nitro-N-nitrosoguanidine-induced transformation and increases chromosomal aberrations. Proc Natl Acad Sci U S A. 1980 Nov;77(11):6649-53.?
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